PURPOSE OF THE REVIEW Inherited autoinflammatory syndromes are conditions caused by mutations of proteins playing a pivotal role in the regulation of the innate immunity leading to an uncontrolled inflammation. The understanding of the molecular pathways involved in these disorders has shed a new light on the pattern of activation and maintenance of the inflammatory response and disclosed new m...

1. Distinguish between biologic DMARD use and nonbiologic DMARD use in the treatment of rheumatoid arthritis (RA). 2. Assess the differences between classes of biologic disease-modifying antirheumatic drug (DMARD) therapy. 3. Based on individual patient characteristics, construct a treatment and monitoring plan for a patient with RA and, when appropriate, include biologic DMARD therapy. 4. Just...

This consensus document reviews the evidence on the evaluation of biological drugs. The main conclusions of the group are: a) the current evidence on biological comparisons is based on indirect comparisons and is generally unreliable and with important methodological limitations. Therefore, b) it is considered necessary to amend the regulatory directives in the sense of strongly favoring random...

Chronic Urticaria (CU) is a skin disorder characterized by wheal and flare with duration of more than 6 weeks affecting 1%-2% the population (more common in women). Thirty to 35% cases CU have angioedema [1]. The etiology chronic spontaneous urticarial not usually clear, 40%-50% are idiopathic 30%-40% autoimmune [2, 3]. Quality life disturbed which has direct relation severity [4].

Biologic drugs have revolutionised many medical conditions. Like all medicines there is a role for therapeutic drug monitoring (TDM) with some agents in The utility of TDM biologic will be explored, covering methods detection as well the evidence that effective or otherwise.